Classics in Total Synthesis. By K.C. Nicolaou and E. J. Sorensen. Article (PDF Available) in Molecules 3(2) · February with 2, Reads. This book is essential for any synthetic organic chemist.[ ]. K. C. NICOLAOU, E. J. SORENSEN. CLASSICS IN. TOTAL. Page 2. Classics in Total Synthesis K. C. Nicolaou and. – E. J. Sorensen. VCH.

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Shipping Add to Cart. This series can therefore already be justifiably called a classic in itself.

Would you like to change to the site? Nicolaou – Winner of the Nemitsas Prize in Chemistry This book is a must for every synthetic chemist. Most synthesis of natural products require a special skill: NicolaouJason S. Reaction sequences and synthetically crucial steps are presented in blue boxed sections. The selected examples cover a large range of methods and very important natural products.

He explains all the key steps of the synthetic pathway, highlighting the major developments in blue-boxed sections and contrasting these to other synthetic methods. This alone is one of the great strengths of the book, and provides every synthetic chemist with an excellent pool for the solution of his or her own synthetic problems.

Targets, Strategies, Methods K.

Book Review: Classics in Total Synthesis – K. C. Nicolaou, E. J. Sorensen

Novelties of this third volume compared to the previous ones are mainly concerned with the detailed contents. Nicolaou has made outstanding contributions in his research field.

All literature references are clearly identified by chapter endnotes, thus allowing rapid access to the primary sources. His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens. Nicolaou compiles in this textbook the important synthetic methods that lead to a complex molecule with valuable properties. The syntheses, together with historical excursions, have been taken from literature of the years to The present volume – and hopefully future books of this series – offer an exciting and outstanding overview of the subject of natural products total syntheses in its complexity and variety.

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He is the recipient of many prizes, awards and honors. Further Targets, Sjnthesis, Methods K. On the other hand, the great success of this series does support a continuation of the style in its present form. Nicolaou compiles and contrasts the important synthet. He tota, is a post-doctoral fellow in Professor Nicolaou’s laboratory.

After two years as a medicinal chemist at Enanta Pharmaceuticals, he began graduate studies at The Scripps Research Institute under the guidance of Professor K.

A particularly extensive account is given in Chapter 3, which describes an impressive 60 g total synthesis of discodermolide by Novartis.

Site Search any all words. But of that multitude, only a few books have been as outstanding in recent years as the series Classics in Total Synthesis, written by K. Nicolaou has earned three prestigious international honors recently, including the Nemitsas Ttotal in Chemistry. The authors carefully explain each synthetic step and give hints on alternative methods and potential pitfalls.

Wiley-VCH – Classics in Total Synthesis III

A wonderful tool for learning and teaching and a must-have for all current and future organic and biochemists. Would you like to change to the site? Retrosynthetic analyses, reaction sequences, and stereochemically crucial steps are presented in boxed sections within the text.

Similar to its predecessors and completing the trilogy, this textbook analyzes the syntheses in a didactic manner, with several chapters including mini-reviews of key methodologies, and an emphasis on the history, mechanism, scope, and generality classifs the reactions. Retaining his excellent, proven approach, world-famous chemist and passionate teacher K. It is amazing, as in the 50’s, how projects like the synthesis of penicillin were advanced.

The book includes the years to and is for this reason, both, a kind of historical book and a reference book. And due to the excellent presentation of reaction mechanisms and very good explanations of selected reactions, it is a beautiful teaching classic for the advanced student, in order to deepen the knowledge acquired in the study.

After describing retrosyntheses that have been achieved, and any preliminary synthetic work, the chapter gives a very detailed description of the synthesis of the target structure, including almost all the individual steps. About the Author K. In contrast to the first two volumes, this new one features full-color frontispieces.


His impact on chemistry flows from his works in chemical synthesis and chemical biology described in over publications and 55 patents. The totxl instructive concept of discussing and comparing several different syntheses of a target structure in a parallel fashion, which was introduced in the second volume of this series, has now been further developed in a clever way.

Classics in Nicollaou Synthesis: Planning, current methods and even the development of completely new synthesis methods are required, because the tools of nature are many times not available or are completely unknown! He is the recipient of many prizes, awards and honors. Sometimes it would also have been useful for the synthetic chemist reader to be given an explanation of why a specific unusual reagent was chosen at a certain stage during the planning or carrying out of a synthesis, and why an apparently more convenient and conventional procedure was avoided.

Description Content Reviews Author information Retaining his excellent, proven approach, world-famous chemist and passionate teacher K. The introductions to the chapters often feature insights into the biosynthesis of the natural product classsics e. Thus, one finds surveys on current topics of interest such as organocatalysis Chapter 7: His impact on chemistry, biology and medicine flows from his research works in chemical synthesis and chemical biology described in numerous publications and patens.

Classics in Total Synthesis III

Such explanations, and possibly also descriptions of unsuccessful attempted routes, could give the reader an even more detailed insight into problems of reactivity or selectivity of a specific reagent or substrate. Added to Your Classkcs Cart.

Home Subjects Chemistry Organic Chemistry. Numerous references to useful reviews and the original literature make this book an indispensable source of further information.