ERTAPENEM PACKAGE INSERT PDF

For Package Inserts, please click on the NDC#. Presentation(s):1g; Reference Listed Drug:Invanz®; Therapeutic Class: Antibacterial, carbapenem type. INVANZ 1 g powder for concentrate for solution for infusion. 2. . This medicinal product contains approximately mEq (approximately mg) of sodium per g dose which should Package Leaflet: information for the user. INVANZ 1 . Product Availability · Contact Us · Make An Inquiry. () Product Summary. Ertapenem Sodium Injection. Therapeutic Class: Carbapenem Antibiotic.

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Dilute the entire contents of the reconstituted vial in 50 mL of 0. Sodium picosulfate; Magnesium oxide; Anhydrous citric acid: For the treatment of complicated intraabdominal infections.

Immediately transfer the appropriate amount of the reconstituted vial to diluent. Ertapenem is contraindicated in any patient who has exhibited hypersensitivity to ertapenem, other drugs in the same class e. Prescribing ertapenem in the absence of a proven or pacakge suspected bacterial infection or for a prophylactic indication iinsert unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria.

It was concluded that the antibiotics ampicillin, ciprofloxacin, clarithromycin, doxycycline, metronidazole, ofloxacin, roxithromycin, temafloxacin, and tetracycline did not alter plasma concentrations of OCs.

Practitioners should be aware that antibiotic-associated colitis has been observed to occur over two months or more following discontinuation of systemic antibiotic therapy; a careful medical history should be taken. Shake well to dissolve. Packaage is the diluent for IM administration of ertapenem. It is known that systemic use of antibiotics predisposes patients to development of pseudomembranous colitis.

Products inhibiting peristalsis are contraindicated in this clinical situation. If ertapenem is given 6 hours or more prior to hemodialysis, no supplemental ibsert is required. Reconstitute each 1 g vial with 10 mL of 0.

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Ertapenem is structurally similar to the penicillins and cephalosporins and these patients may be more susceptible to hypersensitivity reactions. IM use is contraindicated in patients with an amide local anesthetic hypersensitivity. Data regarding progestin-only contraceptives ertapenfm for newer combined contraceptive deliveries e.

Use with a needless IV system is not recommended. One retrospective study reviewed the literature to determine the effects of oral antibiotics on the pharmacokinetics of contraceptive estrogens and progestins, and also examined clinical studies in which the incidence of pregnancy with OCs and antibiotics was reported.

Accumulation does not occur following multiple IM doses in healthy adults. In general, unless the infant is allergic to ertapenem, breast-feeding is likely safe during maternal carbapenem therapy; observe the infant for potential effects. Infuse IV over 30 minutes. The toxin produced by Clostridium difficile is a primary cause of pseudomembranous colitis. It exhibits non-linear pharmacokinetics due to a high level of concentration-dependent plasma protein binding to albumin.

Do not co-infuse with other medications. Guidelines recommend ertapenem for mixed necrotizing infections.

Ertapenem Sodium Injection – Par Sterile Products – Products

Dilute the appropriate volume of the reconstituted solution based on body weight in 0. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. If possible, avoid coadministration. Consideration should be given to the diagnosis of pseudomembranous colitis in patients presenting with diarrhea following antibacterial administration. Patients at greater risk for seizures may include: However, it is theorized that a combination of resistance mechanisms is required for significant carbapenem resistance.

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However, specific intrinsic pafkage acquired beta-lactamases, generally called carbapenemases, can hydrolyze the carbapenems. Reconstitute the 1 g vial with 3. Ertapenem is administered via intravenous IV or intramuscular IM routes. For surgical infection prophylaxis for elective colorectal surgery.

It inhibits the third and final stage of bacterial cell wall synthesis by preferentially binding to specific penicillin-binding proteins PBPs that are located inside the bacterial cell wall. For less than 1 g dose: Immediately withdraw the appropriate dose and inject deeply into a large muscle i.

Infants and Children 3 months to 12 years. If an allergic reaction occurs, discontinue the drug and initiate appropriate emergency treatment with epinephrine, oxygen, IV steroids, intubation or other therapy as indicated.

For 1 g dose: PAE is defined as the suppression of bacterial growth that continues after the antibiotic concentration falls below the ertqpenem MIC. Therefore, these antibiotics should egtapenem taken at least 2 hours before and not less than 6 hours after the administration of sodium picosulfate; pwckage oxide; anhydrous citric acid solution. Like meropenem, but unlike imipenem, it has a 1-beta-methyl substituent and does not require protection with an inhibitor of human renal dihydropeptidase I.

These authors concluded that because females most at risk for OC failure or noncompliance may not be easily identified and the true incidence of such events may be under-reported, and given the serious consequence of unwanted pregnancy, that recommending an additional method of contraception during short-term antibiotic use may be justified.