Two elderly patients with a history of either cerebral vascular accident (CVA) or head trauma and no evidence of renal disease developed seizures while. exantema y prurito. La toxicidad neurológica, aunque rara, es más frecuente tras la administración de Imipenem/Cilastatina. La aparición de convulsiones con. Incidence Most antibiotics are CNS-safe, and neurotoxicity associated with their administration is infrequent There have been anecdotal.

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Most seizures are generalized, and partial seizures suggest a focal cerebral lesion.

The risk of seizures among the carbapenems: a meta-analysis.

One patient had simple partial seizures with PML. Hypomagnesemia can induce epileptic seizures, 2728 and Van Paesschen et al 8 emphasize metabolic causes as important in HIV-infected patients. Etiologic and Clinical Aspects.

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The risk of seizures among the carbapenems: a meta-analysis.

Create a free personal account to download free article PDFs, sign up for alerts, and more. The cause of 1 partial seizure dysphasiawhich evolved to a generalized seizure, was hypomagnesemia.

No cause was found in 1 patient, despite a thorough examination. Create a free personal account to download free article PDFs, sign up for alerts, customize your interests, and more.

Unlike previous studies 310 according to our study, toxic-metabolic factors accounted for more than half Sign in to save your search Sign in to your personal account. All 17 patients had a generalized seizure at some time. Similar to other reports, 38 we observed status epilepticus in 3 patients Toxic-metabolic factors were thus the cause of the seizure in 10 patients Any patient with prior seizures with or without relation to HIV was excluded from the study.


Since the number of HIV-infected patients with first seizure in our study is relatively low, seizure characterization is limited. Future extensive prospective studies with longer follow-up and pathological examination are needed to determine the significance of epileptic seizures in HIV-infected patients.

Previous studies have ranged from Seizures were refractory to therapy in 3 patients Any patient with a first seizure during this 1-year period was examined by physicians from the Department of Neurology and followed up quarterly until death or study end.

First seizure in adults: The HIV stage was less advanced in those with no identifiable cause than in imipemem with an identifiable cause.

In other reports, sexual transmission was the most common risk factor. Most patients were treated with phenytoin, which was well tolerated and effective in controlling seizures. Generalized tonic-clonic imiipenem were the most common, and a focal seizure suggested a structural cerebral lesion. A variety of other causes have been associated with HIV-infected patients who have seizures infection, neoplasm, and stroke38 – 101323 – 26 but we did not see these causes in our patients.


The cause of seizures in 2 patients was hypoglycemia and hypomagnesemia. Create a free personal account to access your subscriptions, sign up for alerts, and more.

Carbamazepine therapy was discontinued in both patients because of adverse effects severe skin reaction and ataxia and was changed to phenytoin. In our series, we were unable to identify a presumed cause in only 1 patient in whom the HIV infection alone was the presumed cause.

Clinical data recorded for each patient were age, sex, HIV risk factors, first seizure date, toxic drug use, latency between diagnosis of HIV infection and first seizure, stage of disease, prior anti-HIV treatments, neurologic complications related to HIV, nonneurologic complications, and seizure characteristics duration, interval between seizures, precipitating drugs, frequency, and clinical seizure type based on the International Classification of Epileptic Seizures of 7.

In 1 patient, imipenem produced a GTC seizure, a well-known adverse effect.

We were able to identify the cause of seizure in In 3 patients Neurological complications of acquired immunodeficiency syndrome: Create a personal account to register for email alerts with links to free full-text articles.